EXPERIMENTAL RESEARCH IN SYPHILIS

Studies in Experimental Syphilis

1. The size of the dose of the infecting material exerts an appreciable effect upon the duration of the incubation period in experimental syphilis of the rabbit. Other things being equal, the larger the dose the shorter is the incubation period. 2. The size of the inoculum was not found to exercise any marked effect upon the course of the disease as a whole. 3. In individual rabbits inoculated ...

Experimental Syphilis in the Rabbit

In a series of more than 200 rabbits in which generalized lesions were observed following local inoculation with Treponema pallidum, there were a number of animals in which characteristic lesions were noted upon mucous membranes or along mucocutaneous borders. These lesions were distributed with about equal frequency between the nose or nasolacrimal system and the eyelids on the one hand, and t...

Experimental rabbit syphilis.

Experimental Ocular Syphilis and Neurosyphilis.

The challenge in clinical syphilis to-day is the detection of the disease in the sero-negative patient. The magnitude of this problem is evident when one considers that over 100 cases of ocular syphilis and neurosyphilis have been encountered in this institution within the past year (Smith, 1964; Smith and Moore, 1964; Smith and Taylor, 1965). Ofparamount importance is the fact that the majorit...

Experimental syphilis: guinea pig model.

Outbred Hartley male guinea pigs (300-400 g) were infected intradermally with various concentrations of Treponema pallidum Nichols strain in the pubic region. The median lethal dose (ID50) was approximately 10(5). The animals produced lesions visible by darkfield microscopy, treponemal antibodies (IgG only), and histopathological changes in the lymphoid organs. Though less susceptible to T pall...